ea0037gp.02.06 | Adrenal (1) | ECE2015
Resmini Eugenia
, Santos Alicia
, Aulinas Anna
, Webb Susan
, Gomez-Anson Beatriz
, Cox Olivia
, Lee Richard
Introduction: FKBP5 is a protein that regulates glucocorticoid receptor sensitivity, via an ultra-short negative feedback mechanism. Variations in the FKBP5 gene can influence the response to glucocorticoids (GC). Hypercortisolaemia plays a role on impairment of brain function and could be mediated by epigenetic variations of the FKBP5 gene. Cushings syndrome (CS), a disease characterized by hypercortisolaemia, is associated with memory deficits, lower ...